Tirzepatide is not safe for everyone. Be straight with your provider about your health history. It exists to protect you.
Do not take tirzepatide if you have:
A personal or family history of medullary thyroid carcinoma (MTC) or Multiple Endocrine Neoplasia type 2 (MEN 2). This is a boxed warning.
A serious hypersensitivity (allergy) to tirzepatide or any of its components.
A current or planned pregnancy. Tirzepatide is not for use during pregnancy. Stop immediately if you learn you are pregnant, and talk to your provider before trying to conceive.
Use extra caution if you have:
A history of pancreatitis.
Gallbladder disease or risk factors. Rapid weight loss can increase the risk of gallstones.
Kidney concerns. Dehydration from persistent vomiting or diarrhea can lead to acute kidney injury. Push fluids, and pause the medication if vomiting or diarrhea won't stop.
Diabetic retinopathy. Complications can occur during rapid improvement in blood sugar.
Severe GI disease, including gastroparesis.
An upcoming procedure requiring general anesthesia or deep sedation. Tirzepatide slows stomach emptying, which raises aspiration risk. Tell your surgical team you are on it.
Bottom line
Tell your provider about every medical condition and every medication you take before starting, and any time something changes. If any of the above applies to you, that conversation matters more, not less.